A consortium to develop next-generation influenza vaccines to protect citizens worldwide

We are a consortium of fourteen partners, aiming to maximize the development and implementation of next-generation influenza vaccine candidate(s) with broader and longer-lasting protection. The project is named “ENDFLU”, acronym for Evaluation of ratioNally Designed inFLUenza vaccines.

The ENDFLU consortium includes key opinion leaders (KOLs) and experts from Europe and India with strong international standing in influenza vaccine development, including both scientific/technical in-depth understanding of the virus and immunological processes, and with access to all preclinical/nonclinical relevant models for efficacy (and safety) testing, and early phase clinical development.

The Consortium

University of Veterinary Medicine Hannover (TiHo)

The University of Veterinary Medicine Hannover, Foundation (TiHo) is a nationally and internationally recognized institution of higher education, known for its excellence in veterinary science and its interdisciplinary focus.

Principal Investigators: Ab Osterhaus, Guus Rimmelzwaan

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Indian Institute of Science

Established in 1909, the Indian Institute of Science (IISc) is India’s leading institution of advanced education and research in the sciences and in engineering.

Principal Investigator: Raghavan Varadarajan

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VIB is a Centre of Excellence in life sciences in Flanders, Belgium. VIB develops and disseminates a wide range of science-based information about all aspects of biotechnology. The CMB research groups have a longstanding reputation in different fields of protein biology.

Principal Investigator: Xavier Saelens

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Lund University

Lund University performs outstanding research in many different fields. The Department of Biochemistry and Structural Biology focuses on modern biochemistry and molecular biology, to address membrane protein structure and function; enzyme structure and function; molecular interactions and molecular assemblies; bio-electrochemistry; RNA, DNA and viruses; structural biology of enzymes and large macromolecular assemblies.

Principal Investigator: Ingemar André

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Translational Health Science and Technology Institute (THSTI)

THSTI develops world-class research and translational programmes on i) vaccines, ii) maternal and child health, iii) point-of-care diagnostics, iv) metabolic diseases and nutrition, and v) training in clinical and product development. The Small Animal Facility at THSTI, a new state-of-the art, high- quality lab animal facility serves as a national resource in support of the important and emerging infectious diseases research agenda that stands ready to assist local, state and national public health efforts.

Principal Investigator: Sweety Samal

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Utrecht University

Utrecht University (UU), one of the largest in Europe, is consistently rated the top Dutch university (Shanghai Ranking). The Faculty of Veterinary Medicine addresses fundamental and strategic research in the fields of animal health, diseases and welfare, and into related aspects of public health and the environment. The Department of Infectious Diseases & Immunology is renowned for its expertise in the field of clinical veterinary infectiology, immunology, infection biology, virology, molecular resistance and tick diseases.

Principal Investigator: Cornelis de Haan

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Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM)

The Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM) is dedicated to
scientific research and science education of international standards. The School of Biology (SOB) at IISER TVM is specialized in Cell Biology, Immunology, Virology, Microbiology, Developmental biology, Ecology and plant biology.

Principal Investigator: Stalin Victor Raj

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Manipal Academy of Higher Education

Manipal Academy of Higher Education is a higher education institution, and home to various centers of excellence. The Manipal institute of Virology (MIV) is a centre for diagnostic virology and research activities.

Principal Investigator: Anita Jagadesh

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Ludwig Maximilian University (LMU) of Munich

Ludwig-Maximilians-Universität München is a leading teaching and research university. The Institute for Infectious Diseases and Zoonoses focuses mainly on virology, in addition to microbiology and mycology.

Principal Investigator: Gerd Sutter

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Seth GS Medical College & KEM Hospital Diamond Jubilee Society

Seth GSMC & KEM are amongst the foremost teaching and medical care providing institutions in India. The Department of Clinical Pharmacology is primarily a teaching and research-oriented department in these institutions. It provides routine patient care facilities like therapeutic drug monitoring and pharmacogenetics.

Principal Investigator: Nithya Gogtay

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Ecole Polytechnique Federale de Lausanne (EPFL)

EPFL has both a Swiss and international vocation and focuses on three missions: teaching, research, and innovation, with a diverse, committed and stimulating research community that is active over a wide spectrum of quantitative and design-focused disciplines. The Laboratory of Protein Design & Immunoengineering (LPDI) specializes in designing novel functional proteins to be used for practical purposes such as therapeutics, vaccines, biosensors, and others.

Principal Investigator: Bruno Correia

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Council of Scientific and Industrial Research (CSIR)

The CSIR Institute of Microbial Technology focuses its research on basic and application-oriented broad thematic areas. These include Molecular biology and microbial genetics, Cell biology and immunology, Protein science and engineering, and Fermentation technology and applied microbiology.

Principal Investigator: Deepak Sharma


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Mynvax Pvt. Ltd.

Mynvax Pvt. Ltd., is a pre-clinical stage biotechnology company [SME]. Mynvax is involved in the development of next-generation vaccines for influenza, using a recombinant technology that will be used to create broadly protective vaccines that may not require annual updating.

Principal Investigator: Gautham Nadig


CR2O B.V. is a full service CRO for public organizations, biotech and pharma industries. CR2O combines strong scientific leadership and operational excellence to conduct innovative national and global clinical trials. CR2O built extensive experience managing and implementing phase I-IV clinical trials.

Principal Investigator: Hadil Es-Sbai

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The ENDFLU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 874650.